Scientific Session 1

CMI-P-45

Doron Shabat

Tel Aviv University

Professor

Israel

chdoron@tauex.tau.ac.il

https://www.shabatlab.sites.tau.ac.il/

Chemiluminsence, Molecular sensores, Bioorganic chemistry

ACADEMIC CAREER

1987-1990 Technion, Haifa, Israel Chemistry B.Sc 1990-1997 Technion, Haifa, Israel Organic Chemistry Ph.D 1997-2000 The Scripps Research Institute, La Jolla, Ca. Research-Associate 2000-2004 Tel-Aviv University Senior Lecturer 2004-2005 Tel-Aviv University Senior Lecturer (Tenure) 2005-2009 Tel-Aviv University Associate Professor 2009-2016 Tel-Aviv University Full Professor 2016-Present Tel-Aviv University The Emerico Letay Chair of Chemical Processes

SELECTED PUBLICATIONS

David, M., Leirikh, T., Naama, N., Kopp, T., Shabat, D., “Phenylamine-1,2-Dioxetanes: Promising Class of Chemiluminescent Luminophores for Aqueous Sensing and Bacterial Detection”, Angew. Chem. Int. Ed., 2025, doi.org/10.1002/anie.202515674.
David, M., Gutkin, S., Nithun, R.V., Jbara, M., Shabat., “Unprecedented Photoinduced-Electron-Transfer Probe with a Turn-ON Chemiluminescence Mode-of-Action”, Angew. Chem., 2024, e202417924.
Shelef, O., Kopp, T., Tannous, T., Jospe-Kaufman, M., Arutkin, M., Reuveni, S., Shabat, D., Fridman, M. “Enzymatic Activity Profiling Using an Ultra-Sensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization”, J. Am. Chem. Soc., 2024, 146, 5263–5273.
Tannous, R., Shelef, O., Gutkin, S., David, M., Leirikh, T., Ge, L., Jaber, J., Zhou, Q., Ma, P., Fridman, M., Spitz, U., Houk, K.N., Shabat, D., “Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays”, ACS. Cent. Sci., 2024, 10, 28–42.
Hananya, N., Shabat, D., “Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in Water”, ACS Central Sci., 2019, 5, 949-59.
Green, O., Eilon, T., Hananya, N., Gutkin, S., Bauer, CR., Shabat, D. “Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes”, ACS Cent. Sci., 2017, 4, 349-58.

WHY MY LAB?

My lab has expertise in the design and synthesis of highly efficient chemiluminescence probes for enzymatic detection and molecular imaging.

CMI-P-01

Motonari Uesugi

Kyoto University

Japan

Chemical biology, Chemoproteomics, Self-assembly, Chemical immunology

CMI-P-02

Kazuya Kikuchi

The University of Osaka

Japan

Molecular imaging, MRI, Fluorescent probes, Photo-activation

CMI-P-03

Takeaki Ozawa

The University of Tokyo

Japan

Fluorescence imaging, Bioluminescence analysis, Optogenetics

CMI-P-04

Midori Arai

Keio University

Japan

Natural products chemistry, Chemical biology, Organic chemistry

CMI-P-05

Takayoshi Suzuki

The University of Osaka

Japan

Medicinal chemistry, Epigenetics, New modality

CMI-P-06

Hideaki Kakeya

Kyoto University

Japan

Natural product chemistry, Chemical biology, Medicinal chemistry

CMI-P-07

Youhei Sohma

Wakayama Medical University

Japan

Peptide chemistry, Amyloid, Catalysis

CMI-P-08

Hiroyuki Nakamura

Institute of Science Tokyo

Japan

Medicinal chemistry, Cancer therapy, Protein modification

CMI-P-09

Akio Ojida

Kyushu University

Japan

Chemical biology, Medicinal chemistry

CMI-P-10

Shinya Hagihara

RIKEN

Japan

Plant chemical biology, Sustainable agriculture, New breeding technology

CMI-P-11

Masaki Kita

Nagoya University

Japan

Chemical biology, Natural products chemistry, Bioorganic chemistry

CMI-P-12

Go Hirai

Kyushu University

Japan

Bioorganic chemistry, Organic synthesis, Glycans, Lipids

CMI-P-13

Tasuku Hirayama

Gifu Pharmaceutical University

Japan

Imaging, Fluorescent probes, Bioinorganic chemistry

CMI-P-14

Fumika Yakushiji

Nagasaki University

Japan

Chemical epigenetics, Chemical probes, Synthetic organic chemistry, Peptide, Small molecules

CMI-P-15

Yuki Goto

Kyoto University

Japan

Peptides, Natural Products, Biosynthesis

CMI-P-16

Mikiko Sodeoka

RIKEN

Japan

Raman imaging, Affinity labeling, Cell death

CMI-P-17

Minoru Yoshida

RIKEN

Japan

Chemical genomics, Drug discovery, Target identification

CMI-P-18

Fumi Nagatsugi

Tohoku University

Japan

Nucleic acids chemistry, Organic chemistry, Chemical biology

CMI-P-19

Masaya Imoto

Juntendo University

Japan

Cell biology, Biochemistry, Chemical biology

CMI-P-20

Ho Jeong Kwon

Yonsei University

South Korea

Chemical biology, Chemical genomics, Chemical proteomics, Organelle interaction, Autophagy

CMI-P-21

Yongseok Choi

Korea University

South Korea

Medicinal chemistry, Autoimmune diseases, Fibrosis

CMI-P-22

Sun Choi

Ewha Womans University

South Korea

AI and computer-aided drug design, Computational medicinal chemistry, Drug discovery

CMI-P-23

Young-Tae Chang

POSTECH

South Korea

Chemical based aging research, Fluorescent imaging, Fluorescent probe, Cell selective probe, Reverse aging

CMI-P-24

Ja-Hyoung Ryu

UNIST

South Korea

Peptide assembly, PPI mimic, Supramolecular chemistry

CMI-P-25

Jun-Seok Lee

Seoul National University

South Korea

Fluorescent probe, Chemoproteomics, Drug mode of action

CMI-P-26

Hyun-Suk Lim

POSTECH

South Korea

Drug discovery, Targeted protein degradation, DNA-encoded library

CMI-P-27

Yan-Mei Li

Tsinghua University

China

PTMs of protein, Vaccine, cGAS-STING

CMI-P-28

Ming-Wei Wang

Research Center for Deepsea Bioresources

China

GPCR, PI3K alpha, Structural pharmacology, Drug discovery, Nanobody

CMI-P-29

Dan Yang

Westlake University

China

Disease mechanism, Fluorescent sensors, Molecular imaging, Proteomics, Drug development

CMI-P-30

YongXiang Chen

Tsinghua University

China

Protein and peptide chemistry, Protein modification, Phosphorus chemical biology, Biomedical application

CMI-P-31

Xiaoguang Lei

Peking University

China

Natural product, Chemical genetics, Drug discovery, Biosynthesis, Biocatalysis

CMI-P-32

Qian Zhao

Hong Kong Polytechnic Univeristy

China

Proteomics, Natural novel peptides, Mass spectrometry

CMI-P-33

Dehua Yang

Shanghai Institute of Materia Medica, CAS

China

GPCRs, GLP-1R, High-throughput screening, Signal transduction, Receptor pharmacology

CMI-P-34

Huan Wang

Nanjing University

China

Peptide, Protein, Enzyme, Natural product, Synthetic biology

CMI-P-35

Xin Zhang

Westlake University

China

Chemical biology, Biological chemistry, Fluorescent microscopy, Synthetic chemistry

CMI-P-36

Liyun Zhang

Nankai University

China

Synthetic biology, Biosensor, Biocatalysis

CMI-P-37

Zou Peng

Peking University

China

Proximity labeling, Voltage imaging, Neuroscience, Membraneless organelles

CMI-P-38

Bengang Xing

Hong Kong Polytechnic Univeristy

China

Chemical biology, Molecular probe & imaging, Bio-labeling, Molecular therapeutics, Nano-theranostics

CMI-P-39

Jing Yu

Tsinghua University

China

Biophysics, Assembly of biomacromolecules, Condensation of biomolecules

CMI-P-40

Shi-Zhong Luo

Beijing University of Chemical Technology

China

Bioactive peptide, Cell surface protein phase separation, Peptide drug, Drug delivery

CMI-P-41

Sandeep Verma

IIT Kanpur

India

Chemical neuroscience, Microfluidic devices, New antibiotics

CMI-P-42

Govindaraju Thimmaiah

JNCASR

India

Neurodegenerative diseases, Redox biology, Ferroptosis and cuproptosis, Neuroinflammation, Theranostics (diagnostic therapy)

CMI-P-43

Eylon Yavin

The Hebrew University

Israel

PNA, RNA sensors, Antisense, Fluorogenic dyes

CMI-P-44

Micha Fridman

Tel Aviv University

Israel

Antimicrobial agents, Fluorescent antifungal probes, Drug resistance and tolerance, Subcellular localization of small molecules

CMI-P-45

Doron Shabat

Tel Aviv University

Israel

Chemiluminsence, Molecular sensores, Bioorganic chemistry

CMI-P-46

Yuval Ebenstein

Tel Aviv University

Israel

Genomics and epigenetics, Fluorescence microscopy, Diagnostics

CMI-P-47

Amir Goldbourt

Tel Aviv University

Israel

Solid state nuclear magnetic resonance, Structural virology, NMR methods and developments

CMI-P-48

Chayasith Tao Uttamapinant

VISTEC

Thailand

Genetic code expansion, Liquid-liquid phase separation, Synthetic biology, Plastic waste bioremediation, Infectious diseases

CMI-P-49

Jay Chanat Aonbangkhen

Chulalongkorn University

Thailand

Chemical probes, Fluorescent dyes, Proteomics, Bioactive peptides, Cancer cell signaling

CMI-P-50

Jiranan Chotitumnavee

Mahidol University

Thailand

Epigenetics, Cancers, Pharmacology, Medicinal chemistry