Scientific Session 2

CMI-P-27

Yan-Mei Li

Tsinghua University

Professor

China

liym@mail.tsinghua.edu.cn

https://www.chem.tsinghua.edu.cn/info/1095/2227.htm

PTMs of protein, Vaccine, cGAS-STING

ACADEMIC CAREER

B.S., 1987, Tsinghua University; Master, 1989, Tsinghua University; Ph.D., 1992, Tsinghua University (advisor: Yu-Fen Zhao); Postdoctoral Training, 1996-1997, Karlsruhe University (advisor: Herbert Waldmann); Lecture, 1992-1993, Tsinghua University; Assistant Professor, 1993-1998, Tsinghua University; Professor, 1998-present, Tsinghua University

SELECTED PUBLICATIONS

Shao-Hua Zhuo‡, Tian-Yang Wang‡, Lang Zhao, Jing-Yun Su, Jin-Jian Hu, Yu-Fen Zhao and Yan-Mei Li* “piSTING: A Pocket-Independent Agonist Based on Multivalency-Driven STING Oligomerization” Angewandte Chemie- International Edition, 2024, 63(38):e202407037 DOI: 10.1002/anie.202407037
Pei-Yang He†, Yusai Zhou†, Pu-Guang Chen†, Meng-Qian Zhang†, Jin-Jian Hu, Yeh-Jun Lim, Hongjie Zhang, Kai Liu* and Yan-Mei Li* “A Hydroxylamine-Mediated Amidination of Lysine Residues That Retains the Protein's Positive Charge” Angewandte Chemie- International Edition, 2024, 63, e202402880 DOI: 10.1002/anie.202402880
Jinjian Hu†, Wencheng Xia†, Shuyi Zeng†, Yeh-Jun Lim†, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu*, Yan-Mei Li* “Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures” Nature Communications, 2024, 15, article number 2677 DOI: 10.1038/s41467-024-46898-1
Wen-Hao Li, Jing-Yun Su, Yan-Mei Li* “Rational Design of T-Cell- and B-Cell-based Therapeutic Cancer Vaccines” Accounts of Chemical Research, 2022, 55(18), 2660-2671 (supplementary cover) DOI: 10.1021/acs.accounts.2c00360
Yemima Butler#, Yu-Qing Liu#, Ramhari Kumbhar, Peiran Zhao, Kundlik Ghadave, Ning Wang, Yan-Mei Li, Xiaobo Mao*, and Wenjing Wang* “α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice” Nature Communications, 2022, 13, Article number: 4060 DOI: 10.1038/s41467-022-31787-2
Mengqian Zhang, Peiyang He and Yanmei Li* “Light-Initiated 1,3-Dipolar Cycloaddition Between Dehydroalanines and Tetrazoles: Application to Late-Stage Peptide and Protein Modifications” Chemical Science, 2023, 14, 9418 - 9426 DOI: 10.1039/D3SC02818F
Shengnan Zhang#, Yu-Qing Liu#, Chunyu Jia#, Yeh-Jun Lim#, Guoqin Feng#, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu Wang, Zhenying Liu, Jin-Jian Hu, Meng-Rong Ma, Zhijun Liu, Lin Jiang, Dan Li, Renxiao Wang, Valina L. Dawson, Ted M. Dawson*, Yan-Mei Li*, Xiaobo Mao*, Cong Liu* “Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease” Proc Natl Acad Sci USA, 2021, 118 (26), e2011196118; DOI: 10.1073/pnas.2011196118
Kun Zhao#, Yeh-Jun Lim#, Zhenying Liu#, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li*, Cong Liu* "Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM" Proc Natl Acad Sci USA, 2020, 117(33): 20305-20315 DOI: 10.1073/pnas.1922741117

WHY MY LAB?

Synthesis of modified proteins

CMI-P-01

Motonari Uesugi

Kyoto University

Japan

Chemical biology, Chemoproteomics, Self-assembly, Chemical immunology

CMI-P-02

Kazuya Kikuchi

The University of Osaka

Japan

Molecular imaging, MRI, Fluorescent probes, Photo-activation

CMI-P-03

Takeaki Ozawa

The University of Tokyo

Japan

Fluorescence imaging, Bioluminescence analysis, Optogenetics

CMI-P-04

Midori Arai

Keio University

Japan

Natural products chemistry, Chemical biology, Organic chemistry

CMI-P-05

Takayoshi Suzuki

The University of Osaka

Japan

Medicinal chemistry, Epigenetics, New modality

CMI-P-06

Hideaki Kakeya

Kyoto University

Japan

Natural product chemistry, Chemical biology, Medicinal chemistry

CMI-P-07

Youhei Sohma

Wakayama Medical University

Japan

Peptide chemistry, Amyloid, Catalysis

CMI-P-08

Hiroyuki Nakamura

Institute of Science Tokyo

Japan

Medicinal chemistry, Cancer therapy, Protein modification

CMI-P-09

Akio Ojida

Kyushu University

Japan

Chemical biology, Medicinal chemistry

CMI-P-10

Shinya Hagihara

RIKEN

Japan

Plant chemical biology, Sustainable agriculture, New breeding technology

CMI-P-11

Masaki Kita

Nagoya University

Japan

Chemical biology, Natural products chemistry, Bioorganic chemistry

CMI-P-12

Go Hirai

Kyushu University

Japan

Bioorganic chemistry, Organic synthesis, Glycans, Lipids

CMI-P-13

Tasuku Hirayama

Gifu Pharmaceutical University

Japan

Imaging, Fluorescent probes, Bioinorganic chemistry

CMI-P-14

Fumika Yakushiji

Nagasaki University

Japan

Chemical epigenetics, Chemical probes, Synthetic organic chemistry, Peptide, Small molecules

CMI-P-15

Yuki Goto

Kyoto University

Japan

Peptides, Natural Products, Biosynthesis

CMI-P-16

Mikiko Sodeoka

RIKEN

Japan

Raman imaging, Affinity labeling, Cell death

CMI-P-17

Minoru Yoshida

RIKEN

Japan

Chemical genomics, Drug discovery, Target identification

CMI-P-18

Fumi Nagatsugi

Tohoku University

Japan

Nucleic acids chemistry, Organic chemistry, Chemical biology

CMI-P-19

Masaya Imoto

Juntendo University

Japan

Cell biology, Biochemistry, Chemical biology

CMI-P-20

Ho Jeong Kwon

Yonsei University

South Korea

Chemical biology, Chemical genomics, Chemical proteomics, Organelle interaction, Autophagy

CMI-P-21

Yongseok Choi

Korea University

South Korea

Medicinal chemistry, Autoimmune diseases, Fibrosis

CMI-P-22

Sun Choi

Ewha Womans University

South Korea

AI and computer-aided drug design, Computational medicinal chemistry, Drug discovery

CMI-P-23

Young-Tae Chang

POSTECH

South Korea

Chemical based aging research, Fluorescent imaging, Fluorescent probe, Cell selective probe, Reverse aging

CMI-P-24

Ja-Hyoung Ryu

UNIST

South Korea

Peptide assembly, PPI mimic, Supramolecular chemistry

CMI-P-25

Jun-Seok Lee

Seoul National University

South Korea

Fluorescent probe, Chemoproteomics, Drug mode of action

CMI-P-26

Hyun-Suk Lim

POSTECH

South Korea

Drug discovery, Targeted protein degradation, DNA-encoded library

CMI-P-27

Yan-Mei Li

Tsinghua University

China

PTMs of protein, Vaccine, cGAS-STING

CMI-P-28

Ming-Wei Wang

Research Center for Deepsea Bioresources

China

GPCR, PI3K alpha, Structural pharmacology, Drug discovery, Nanobody

CMI-P-29

Dan Yang

Westlake University

China

Disease mechanism, Fluorescent sensors, Molecular imaging, Proteomics, Drug development

CMI-P-30

YongXiang Chen

Tsinghua University

China

Protein and peptide chemistry, Protein modification, Phosphorus chemical biology, Biomedical application

CMI-P-31

Xiaoguang Lei

Peking University

China

Natural product, Chemical genetics, Drug discovery, Biosynthesis, Biocatalysis

CMI-P-32

Qian Zhao

Hong Kong Polytechnic Univeristy

China

Proteomics, Natural novel peptides, Mass spectrometry

CMI-P-33

Dehua Yang

Shanghai Institute of Materia Medica, CAS

China

GPCRs, GLP-1R, High-throughput screening, Signal transduction, Receptor pharmacology

CMI-P-34

Huan Wang

Nanjing University

China

Peptide, Protein, Enzyme, Natural product, Synthetic biology

CMI-P-35

Xin Zhang

Westlake University

China

Chemical biology, Biological chemistry, Fluorescent microscopy, Synthetic chemistry

CMI-P-36

Liyun Zhang

Nankai University

China

Synthetic biology, Biosensor, Biocatalysis

CMI-P-37

Zou Peng

Peking University

China

Proximity labeling, Voltage imaging, Neuroscience, Membraneless organelles

CMI-P-38

Bengang Xing

Hong Kong Polytechnic Univeristy

China

Chemical biology, Molecular probe & imaging, Bio-labeling, Molecular therapeutics, Nano-theranostics

CMI-P-39

Jing Yu

Tsinghua University

China

Biophysics, Assembly of biomacromolecules, Condensation of biomolecules

CMI-P-40

Shi-Zhong Luo

Beijing University of Chemical Technology

China

Bioactive peptide, Cell surface protein phase separation, Peptide drug, Drug delivery

CMI-P-41

Sandeep Verma

IIT Kanpur

India

Chemical neuroscience, Microfluidic devices, New antibiotics

CMI-P-42

Govindaraju Thimmaiah

JNCASR

India

Neurodegenerative diseases, Redox biology, Ferroptosis and cuproptosis, Neuroinflammation, Theranostics (diagnostic therapy)

CMI-P-43

Eylon Yavin

The Hebrew University

Israel

PNA, RNA sensors, Antisense, Fluorogenic dyes

CMI-P-44

Micha Fridman

Tel Aviv University

Israel

Antimicrobial agents, Fluorescent antifungal probes, Drug resistance and tolerance, Subcellular localization of small molecules

CMI-P-45

Doron Shabat

Tel Aviv University

Israel

Chemiluminsence, Molecular sensores, Bioorganic chemistry

CMI-P-46

Yuval Ebenstein

Tel Aviv University

Israel

Genomics and epigenetics, Fluorescence microscopy, Diagnostics

CMI-P-47

Amir Goldbourt

Tel Aviv University

Israel

Solid state nuclear magnetic resonance, Structural virology, NMR methods and developments

CMI-P-48

Chayasith Tao Uttamapinant

VISTEC

Thailand

Genetic code expansion, Liquid-liquid phase separation, Synthetic biology, Plastic waste bioremediation, Infectious diseases

CMI-P-49

Jay Chanat Aonbangkhen

Chulalongkorn University

Thailand

Chemical probes, Fluorescent dyes, Proteomics, Bioactive peptides, Cancer cell signaling

CMI-P-50

Jiranan Chotitumnavee

Mahidol University

Thailand

Epigenetics, Cancers, Pharmacology, Medicinal chemistry