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Scientific Session 6

CMI-P-16

Mikiko Sodeoka

RIKEN

Director of Center for Sustainable Resource Science

Japan

Raman imaging, Affinity labeling, Cell death

ACADEMIC CAREER

1983, M. Pharm., Chiba Univ. (advisor: Toru Hino); 1989, D. Pharm, (advisor: Masakatsu Shibasaki); 1983-1986, Research Associate, Sagami Chemical Research Center; 1986-1990, Assistant Professor, Hokkaido Univ.; 1990-1992, Postdoctoral Fellow, Harvard Univ. (advisors: E. J. Corey & Gregory L. Verdine); 1992-1995, Assistant Professor, The Univ. of Tokyo; 1996-1999, Group Leader, Sagami Chemical Research Center; 1999-2000, Associate Professor, The Univ. of Tokyo; 2000-2006, Professor, Tohoku Univ.; 2006-2024, Chief Scientist, RIKEN; 2013-present, Group Director and 2025-present, Director RIKEN Center for Sustainable Resource Science.

SELECTED PUBLICATIONS
  • Simple Purification of Small-Molecule-Labeled Peptides via Palladium Enolate Formation from β-Ketoamide Tags. K. Hayamizu et al. Chem. Sci. 2023, 14, 8249

  • Raman Spectroscopy for Chemical Biology Research. K. Dodo et al. J. Am. Chem. Soc. 2022, 144, 19651

  • Dual targeting of DDX3 and eIF4A by the translation inhibitor Rocaglamide A. M. Chen, et al. Cell Chem. Biol. 2021, 28, 475.

  • Development of a Water-Soluble Indolylmeleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis. K. Dodo, et al. ACS Med. Chem. Lett. 2019, 10, 1272

  • Alkyne-tag SERS Screening and Identification of Small-molecule-binding Sites in Protein. J. Ando et al. J. Am. Chem. Soc. 2016, 138, 13901

  • Sphingomyelin Distribution in Lipid Rafts of Artificial Monolayer Membranes Visualized by Raman Microscopy. J. Ando, et al. Proc. Nat. Acad. Sci. 2015, 112, 4546

  • Turn-ON Fluorescent Affinity Labeling Using a Small Bifunctional O-Nitrobenzoxadiazole Unit: Selective Labeling and Imaging of Target Protein, T. Yamaguchi et al. Chem. Sci. 2014, 5, 1021

  • Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells , H. Yamakoshi et al. J. Am. Chem. Soc. 2012, 134, 20681

WHY MY LAB?

My lab can offer affinity labeling method (NBD method) and Raman imaging method.

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